I definitely am a big fan of the SpamTitan clustered mode for high availability as well as checking outbound emails for specific regex strings. We've caught a few people sending information that they shouldn't have through our system
If your organization's email address list was put on a spamming list, SpamTitan is a huge relief. We no longer receive unsolicited emails and everything works really seamlessly.
By filtering out spam, we're able to have users spend less time sifting through their emails and more time being productive in their day to day jobs.