SpamTitan's interface and backend makes it easy for all of our staff to manage spam- before we ran on a Sonicwall email security appliance that would randomly crash, and was slow. Being able to deploy SpamTitan as a VM with clustering features for both of our sites has been a life saver. We hardly ever see spam get through, and when it does, we make sure that we forward it on to the spambank and then it is never a problem again.
I would recommend to make use of SpamTitan support- they are fast, friendly and always happy to help.
We have much less spam on our already strained exchange server. SpamTitan is also a good guard against exchange going down, all mail gets held at the spam filter until it comes back up.